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SUMMARY:Building and extending the body axis: the role of tissue Interface
 s - Pierre-François Lenne\, IBDM and Turing Center for Living Systems\, A
 ix Marseille Univ. &amp\; CNRS\, Marseille\, France 
DTSTART:20251020T133000Z
DTEND:20251020T143000Z
UID:TALK236407@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Abstract: \n\nThe formation of the body axis is a central step
  in embryonic development\; however\, how tissues coordinate to shape and 
 extend it remains largely unknown. Using mouse gastruloids and Xenopus exp
 lants\, we investigated how tissue interactions drive axis elongation. In 
 gastruloids\, we demonstrate that the mechanical properties at tissue inte
 rfaces drive collective cell flows and contribute to axis formation and ea
 rly extension. In Xenopus explants\, we show that coordinated interactions
  between epithelial and mesenchymal layers are essential for robust elonga
 tion. These findings highlight different but potentially conserved strateg
 ies by which tissues build and extend the body axis\, revealing that tissu
 e interfaces can organize coherent axis formation even in the absence of e
 xternal signals.  
LOCATION:in person at Sainsbury Laboratory and online
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