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SUMMARY:Min Ya-The Moment Symmetry Breaks: Spatiotemporal Dynamics of CYCL
 OIDEA Expression During Early Floral Development\; Baptiste Tesson-Complem
 entary Mechanical Identities from Iterative BMP Signaling Ensure Robust Mo
 rphogenesis. - Min Ya\; Baptiste Tesson
DTSTART:20251027T143000Z
DTEND:20251027T153000Z
UID:TALK236410@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Name: Min Ya Affiliation: University of Illinois\, Urbana-Cham
 paign\, USA\n\nTitle: The Moment Symmetry Breaks: Spatiotemporal Dynamics 
 of CYCLOIDEA Expression During Early Floral Development\n\nAbstract: The e
 stablishment of bilateral symmetry in flowers depends on the precise regul
 ation of CYCLOIDEA (CYC) gene expression along the dorsal-ventral axis. Al
 though auxin and BLADE-ON-PETIOLE (BOP) have been implicated as regulators
  of CYC\, when\, where\, and how they affect CYC expression remains unclea
 r. Here\, we combined transgenic manipulation and fluorescent confocal ima
 ging to capture the spatiotemporal dynamics of the Mimulus parishii CYC ge
 nes (MpCYC2a and MpCYC2b) in relation to FM growth and auxin activity maxi
 ma in both wild type (WT) and bop mutants (mpbop). Strikingly\, MpCYCs hav
 e already gained dorsal expression in the FM prior to any detectable auxin
  maxima\, and no difference in MpCYC expression was observed between the w
 ild type and mpbop during this initiation phase. We observed highly dynami
 c auxin maxima during FM expansion\, when MpCYC expressions remained dorsa
 lly restricted in WT but expanded broadly inmpbop FMs. These findings sugg
 est that early symmetry breaking in the FM is guided by positional cues in
 dependent of auxin or BOP\, which are instead essential for refining and m
 aintaining dorsal-specific CYC expression during later FM enlargement. Our
  work illustrated how combining advanced imaging with emerging model syste
 ms can yield fresh insights into long-standing questions in development an
 d evolution\, and laid the groundwork for further elucidating the mechanis
 ms underlying the repeated symmetry breaking in FMs.\n\nName: Baptiste Tes
 son Affiliation: Institut Curie\, Paris\n\nTitle: Complementary Mechanical
  Identities from Iterative BMP Signaling Ensure Robust Morphogenesis\n\nAb
 stract:\n\nMorphogenetic robustness stems from the coordination of signali
 ng cues\, mechanical properties\, and tissue geometry to produce outcomes 
 that resist perturbation. D. melanogaster dorsal closure provides a powerf
 ul model to study this integration. In this process\, the dorsal-most tiss
 ue\, the extraembryonic amnioserosa\, contracts and pulls on the dorsal ep
 idermis\, which elongates in response to enclose the embryo. We show that 
 this system relies on an elastic-to-plastic transition of the dorsal epide
 rmis together with a strengthening of the interface between the two tissue
 s. These properties emerge from iterative phases of DPP/BMP signaling foll
 owing the initial morphogen gradient. This sequential mechanism\, that we 
 defined as automorphy\, instructs tissues with distinct mechanical identit
 ies such as contractile\, plastic\, or adhesive while preserving positiona
 l information. Together\, these mechanical programs provide resilience to 
 developmental perturbations and enable the embryo to adapt to internal org
 an volume\, thereby safeguarding morphogenetic robustness. Our results hig
 hlight how repeated waves of morphogen activity translate patterning into 
 complementary mechanical programs that ensure reliable morphogenesis.
LOCATION:Online
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