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SUMMARY:Travelling waves in our immune system - Ariel Amir\, Weizmann Inst
 itute of Science\, Department of Physics of Complex Systems
DTSTART:20251111T130000Z
DTEND:20251111T140000Z
UID:TALK236557@talks.cam.ac.uk
CONTACT:Tal Agranov
DESCRIPTION:In various biological scenarios\, cells rely on the diffusion 
 of signaling molecules to communicate\, yet information needs to be commu
 nicated quickly and over large distances. How can the limitations of diff
 usion be surpassed? One solution Nature utilizes relies on "diffusive rela
 ys": upon sensing the signal\, cells release more of it\, thus creating an
  outgoing information wave. Mathematically\, this mechanism manifests its
 elf as an additional\, non-linear\, term in the diffusion equation\, allow
 ing for propagating wave solutions. The properties of these waves strongl
 y depend on system dimensionality\, and manifest intriguing phenomena\, in
 cluding regimes where wave velocity is independent of the diffusion consta
 nt. We recently proposed that such waves arise in the immune system\, wher
 e upon sensing a signal\, white blood cells known as neutrophils release a
  signaling molecule. However\, in this case the waves must be self-extingu
 ishing\, since the range of cell recruitment must be limited. After introd
 ucing diffusive relays\, I will discuss new mathematical models of self-ex
 tinguishing relays\, and compare them to recent experiments on neutrophil
 s.
LOCATION:Center for Mathematical Sciences\, Lecture room MR4.
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