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SUMMARY:Cerebellum Computation - Carl Ashworth\; Youjing Yu
DTSTART:20250923T121500Z
DTEND:20250923T114500Z
UID:TALK236635@talks.cam.ac.uk
CONTACT:124819
DESCRIPTION:This week's journal club will discuss the most densely (neuron
 ally) populated area of the brain - the cerebellum\, a region that (notabl
 y) uses about 60% of all the brain's neurons for dimensionality expansion.
 \nIn the first part of the talk\, we will give a basic introduction to the
  physiology and function of the cerebellum as a whole. We will cover the t
 raditionally recognised role of the cerebellum in motor coordination and l
 earning\, discussing the Marr-Albus model of motor learning and illustrati
 ng several limitations and extensions of the original model\, including th
 e role of climbing fibres as error signals. Finally\, we will cover some o
 f the less well known role of the cerebellum in nonmotor domains such as c
 ognition\, pain\, memory\, and sleep.\n\nIn the second part of the talk\, 
 we will look at a more recent paper where Fakharian and colleagues present
 s on how computation in the cerebellum can be predicted by the null space 
 theory\, which states that neurons spike not just to drive movement but al
 so to cancel unwanted effects of other neurons. In marmosets\, each Purkin
 je cell’s spike moves the eyes along a vector. When multiple cells spike
 \, perpendicular contributions cancel\, keeping the population aligned wit
 h the intended movement. Mossy fibers provide motor commands and goals\, w
 hile interneurons transform these signals so Purkinje cells predict when t
 he movement has reached its target. Overall\, the cerebellum computes by b
 oth generating and suppressing neural activity to ensure precise motor con
 trol.\n\nPapers:\n# https://www-annualreviews-org.ezp.lib.cam.ac.uk/conten
 t/journals/10.1146/annurev-neuro-100423-104943\n# https://www-sciencedirec
 t-com.ezp.lib.cam.ac.uk/science/article/pii/S0306452220303961?\n# https://
 www.science.org/doi/10.1126/science.adu6331\n# https://www.science.org/doi
 /10.1126/science.adx8989
LOCATION:CBL Seminar Room\, Engineering Department\, 4th floor Baker build
 ing
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