BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The Many Guises of Reactive Metabolite Signalling - Prof. Yimon Ay
 e - Chemical Biology at the University of Oxford
DTSTART:20250925T130000Z
DTEND:20250925T140000Z
UID:TALK236656@talks.cam.ac.uk
CONTACT:Xani Thorman
DESCRIPTION:We present how a combination of small-molecule chemistry\, che
 mical biology\, and model-organism engineering biology helps to resolve th
 e key mechanistic puzzles surrounding reactive metabolite signalling in he
 alth & disease. Focus will be placed on innovations and applications of in
 terdisciplinary technologies with which we can decode the multifaceted bio
 logy of reactive metabolites in living systems with precise timing\, local
 e\, contexts\, and metabolite-chemotype\, and how the resulting new knowle
 dge illuminates streamlined therapeutic avenues. \nSpeaker bio: \nAye comp
 leted her undergraduate studies in chemistry at Oxford UK (2000-2004)\, an
 d doctoral research in organic chemistry with Prof. David Evans at Harvard
  University (2004-2009). She then switched her research discipline to life
  science and received her postdoctoral training with Prof. JoAnne Stubbe a
 t MIT (2009-2012). Science in the Aye lab seeks to understand non-canonica
 l cell signalling processes. Her laboratory is most well-known for investi
 gations into electrophile signalling\, a nuanced communication mode whereb
 y on-target engagement between specific reactive metabolites and target pr
 oteins\, orchestrates precision responses at cellular/organismal levels. \
 n\nContributions from her team have been recognised by several honours\; r
 ecent examples include: 2025 ERC Advanced Grant\, 2024 UK Academy of Medic
 al Sciences Professorship\, Klaus Grohe Prize in Drug Discovery\, 2022 ERC
  Consolidator Grant\, 2021 Tetrahedron young investigator award\, Internat
 ional Chemical Biology Society Global Lectureship Award for distinguished 
 investigators in chemical biology\, ACS Arthur Cope Scholar\, and 2020 ACS
  Eli Lilly award in biological chemistry.\n
LOCATION:Department of Chemistry\, Cambridge\, Wolfson Lecture Theatre
END:VEVENT
END:VCALENDAR