BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Simplifying Synthesis with Radical Cross-Coupling - Professor Phil
  S. Baran
DTSTART:20251009T140000Z
DTEND:20251009T153000Z
UID:TALK236983@talks.cam.ac.uk
CONTACT:129301
DESCRIPTION:Polar disconnections are intuitive and underlie much of retros
 ynthetic logic. Undergraduates exposed to multistep synthesis are often ta
 ught to assemble organic molecules through the combination of positively a
 nd negatively charged synthons because\, after all\, opposites attract. In
 deed\, the most employed two-electron C–C bond forming reactions today a
 re those either based upon classical cross-coupling reactions (e.g.\, Suzu
 ki\, Negishi\, Heck) or polar additions (aldol\, Michael\, Grignard). Thes
 e reactions are the mainstay of modern synthesis and have revolutionized t
 he way molecules are constructed due to their robust and predictable natur
 e. In contrast\, radical chemistry is sparsely covered beyond the basic pr
 inciples of radical chain processes (i.e.\, radical halogenation). The his
 torical perception of radicals as somewhat uncontrollable species does not
  help the situation. As a result\, synthetic chemists are not prone to mak
 e radical-based strategic bond disconnections during first-pass retrosynth
 etic analyses. In this talk recent studies from our lab will be discussed 
 to illustrate the strategic advantages that can result when unconventional
  radical disconnections are incorporated into synthetic design plans.\n\nT
 alks are priced at £4 for non-Scientific Society members. Scientific Soci
 ety members will have free access to all our talks. Lifetime membership co
 sts £15 and gives free access to all talks\, members-only events and prio
 rity access to oversubscribed SciSoc events.
LOCATION:Pfizer Lecture Theatre\,  Department of Chemistry\, Lensfield Roa
 d
END:VEVENT
END:VCALENDAR