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SUMMARY:Revisiting Hebb and the Hippocampal Index in Humans: Toward a Neur
 otechnology of Memory - Prof Simon Hanslmayr\, University of Glasgow
DTSTART:20251024T153000Z
DTEND:20251024T170000Z
UID:TALK237160@talks.cam.ac.uk
CONTACT:Psychology Reception
DESCRIPTION:In this talk I will present two strands of studies where we in
 vestigated two prominent mechanisms suggested to underlie human episodic m
 emory. First\, Hebbian learning (i.e “fire-together\, wire together”) 
 or Spike-Timing-Dependent-Plasticity (STDP)\, which posits that the firing
  of neurons in close temporal proximity is crucial for laying down a memor
 y trace. Recording the co-firing of single-neuron in epilepsy patients in 
 the medial-temporal-lobe during a memory task we found results that are co
 nsistent with STDP. I will also show results from rhythmic stimulation stu
 dies demonstrating that the manipulation of temporal patterns in the range
  of milliseconds modulates episodic memory formation. A second idea that h
 as influenced memory research is the “Indexing Theory” which posits th
 at the human hippocampus stores episodic memories via an Index – an agno
 stic conjunctive type of code that points to the different elements that b
 elong to the episode. I will present recent evidence from human single neu
 ron recordings where we found neurons that are consistent with such an ind
 exing function. I will also present unpublished results from an ultra-high
 field fMRI at 7T which support these human single unit findings and sugges
 t that the Index is predominantly located in the hippocampal subfield CA3.
  I will close the talk by presenting a recent theoretical framework where 
 we integrate these findings with Concept Cells (so-called Jennifer Annisto
 n cells) and the Engram Allocation Theory. At the end I will speculate how
  results from both streams could lead to the development of novel treatmen
 t for patients with memory problems. \n\nHost: Denes Szucs (ds377@cam.ac.u
 k)\n\nThis talk will be recorded and uploaded to the Zangwill Club "Youtub
 e channel":https://www.youtube.com/@zangwillclub5226 in due course.
LOCATION:Ground Floor Lecture Theatre\, Department of  Psychology
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