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SUMMARY:Quantity and Quality: Mechanisms of Mitochondrial DNA Copy Number 
 and Integrity Control in Saccharomyces cerevisiae - Professor Dr Christof 
 Osman\, Biocenter of the LMU\, Germany
DTSTART:20251112T150000Z
DTEND:20251112T160000Z
UID:TALK239416@talks.cam.ac.uk
CONTACT:Lisa Arnold
DESCRIPTION:Mitochondrial DNA (mtDNA) maintenance relies on mechanisms tha
 t control both the amount and the integrity of the genome. We identify fac
 tors and principles that underlie mtDNA homeostasis and investigate how th
 ey contribute to copy number regulation and quality control. Using S. cere
 visiae as a model\, we apply genetic approaches and quantitative imaging t
 o dissect these processes across different levels of organization\, from m
 olecular interactions to cellular outcomes. Recent work has revealed pathw
 ays that determine mtDNA abundance\, as well as mechanisms that promote th
 e preferential maintenance of functional genomes over defective ones. Toge
 ther\, these findings provide a framework for understanding how eukaryotic
  cells maintain an adequate and functional mitochondrial genome population
 .
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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