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SUMMARY:Modular strategies to decode and rewire cell surface signaling - X
 in Zhou\, Assistant Professor\, Harvard Medical School 
DTSTART:20251124T123000Z
DTEND:20251124T133000Z
UID:TALK239932@talks.cam.ac.uk
CONTACT:Simona Valeviciute
DESCRIPTION:Cell surface proteins are key regulators of cancer and immune 
 cell signaling\, metabolism\, and interactions with the surrounding enviro
 nment. A promising approach to modulating their function is through the co
 ntrol of endocytosis and intracellular trafficking. Under normal physiolog
 ical conditions\, cells use these processes to maintain membrane protein h
 omeostasis and attenuate signaling\, yet their therapeutic potential has o
 nly recently begun to be explored. In this talk\, I will discuss how bispe
 cific antibodies can be designed to modularly control membrane protein end
 ocytosis and signaling\, including those of growth factor receptors and G 
 protein–coupled receptors\, and describe the underlying mechanisms by wh
 ich these molecules function\, with comparisons to traditional antagonists
  and their potential clinical implications. I will also present a protein 
 engineering approach to develop synthetic protein binders that recognize t
 yrosine-phosphorylated signaling motifs\, including sites in PD-1 and LAT\
 , regulators of T cell activity. Using these binders\, we have built senso
 rs and biocircuits to elucidate PD-1 activation with spatiotemporal specif
 icity\, investigate mechanisms of new PD-1 modulators such as anti–PD-1/
 VEGF bispecific antibodies\, and reprogram signaling outcomes to create en
 hanced CAR-T cells.
LOCATION:CRUK CI Lecture Theatre
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