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SUMMARY:Knowledge-based machine learning to extract disease mechanisms fro
 m spatial multi-omics - Julio Saez Rodriguez (EMBL-EBI)
DTSTART:20251114T120000Z
DTEND:20251114T130000Z
UID:TALK240028@talks.cam.ac.uk
CONTACT:Spencer Keene
DESCRIPTION:Abstract: Omics approaches\, in particular those with spatial 
 resolution\, provide unique opportunities to study the deregulation of  in
 tra- and inter-cellular processes in disease using computational approache
 s. The use of prior biological knowledge allows us to reduce the dimension
 ality and increase the interpretability of the data\, in particular by ext
 racting from the data features describing the activity of molecular proces
 ses such as signaling pathways\, gene regulatory networks\, and cell-cell 
 communication events. In this talk\, I will present resources and methods 
 from our group to effectively capture and deploy prior knowledge from the 
 public domain to extract mechanistic information from omics data using com
 putational methods\, and illustrate them in several disease applications.\
 n\nBio:\nJulio Saez-Rodríguez was appointed as EMBL-EBI's Head of Researc
 h in 2024. He leads on the development of the institute’s research missi
 on and vision.\nHis research group explores how large biological datasets 
 can be interrogated with mathematical and AI models\, to unveil the molecu
 lar basis of disease as a means to develop novel therapies. While the rese
 arch is driven by applications\, the group develops free open-source compu
 tational tools\, and benchmarks existing methods\, both within the group a
 nd with the community as part of the DREAM challenges . The current emphas
 is of Julio’s group is on single-cell and spatial data\, multi-omics int
 egration\, and understanding multi-cellular communication. The methods the
 y develop are broadly applicable\, and the group’s focus is on cancer\, 
 autoimmune diseases\, and conditions of the kidney and heart.\nBetween 201
 8 and 2024\, Julio was a Professor of Medical Bioinformatics and Data Anal
 ysis and Director of the Institute for Computational Biomedicine at Heidel
 berg University’s Faculty of Medicine\, as well as a Group Leader at the
  EMBL-Heidelberg University Molecular Medicine Partnership Unit.\nPrevious
 ly\, he was a Professor and Institute Director at RWTH-Aachen University (
 2015-2018)\, and a Group Leader at EMBL-EBI (2010-2015).\n \nJulio did his
  postdoctoral studies at Harvard Medical School and MIT\, after earning a 
 PhD in Process Engineering from the Max-Planck Institute and University of
  Magdeburg in Germany. He has a degree in Chemical Engineering from the Un
 iversity of Oviedo in Spain.\n
LOCATION:Heart and Lung Research Institute (R.101 to 102)
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