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SUMMARY:Understanding The Adverse Health Effects of Air Pollution One Part
 icle at a Time - Dr Allen Haddrell\, University of Bristol
DTSTART:20100524T131500Z
DTEND:20100524T141500Z
UID:TALK24038@talks.cam.ac.uk
CONTACT:Dr Francis Pope
DESCRIPTION:Elevated levels of suspended particles in the troposphere\, te
 rmed particulate matter\, elicit a myriad of adverse health effects in hum
 ans\, ranging from shortness of breath and wheezing to myocardial infarcti
 on and death. It is currently believed that the adverse health effects ass
 ociated with particulate matter are mediated by the inflammatory response 
 initiated by the lung following particulate matter inhalation. What remain
 s an area of much interest is elucidating the specific properties of parti
 culate matter\, physical or chemical\, that cause the upregulation of proi
 nflammatory mediators. The basic premise of this work is to identify the s
 pecific chemical components of particulate matter responsible for its adve
 rse health effects. To address this issue\, instrumentation and methodolog
 y were developed to design\, create\, levitate particles of both known che
 mical composition and size\, alter their composition through heterogeneous
  or multiphase reactions\, followed by their deposition onto lung cells\, 
 in vitro.  The downstream biological response of dosed cells is then measu
 red using a series of standardized assays.  The development and applicatio
 n of this technology will be discussed.
LOCATION:Unilever Lecture Theatre\, Department of Chemistry
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