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SUMMARY:Max Perutz Lecture - Transport through nuclear pores - Dirk Görli
 ch\, Max Planck Institute for Multidisciplinary Sciences
DTSTART:20260119T110000Z
DTEND:20260119T120000Z
UID:TALK240466@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The nucleus must import each and every protein from the cytopl
 asm. On the other hand\, nuclei produce and export tRNAs\, mRNAs and ribos
 omes to the cytoplasm\, where they function in translation. This nucleocyt
 oplasmic transport occurs through nuclear pore complexes (NPCs)\, which ar
 e embedded in the nuclear envelope and are equipped with a sieve-like perm
 eability barrier. This barrier retains inert macromolecules while allowing
  the facilitated passage of nuclear transport receptors (NTRs)\, which in 
 turn shuttle cargo into or out of the nucleus. Indeed\, NPCs are highly ef
 ficient sorting machines\, supporting ~1000 translocation events or a mass
  flow of 100 Megadaltons per second. FG repeat domains are key players in 
 nuclear transport. They are intrinsically disordered\, of low sequence com
 plexity and contain numerous FG (phenylalanine-glycine) dipeptide motifs t
 hat bind NTRs during facilitated translocation. In addition\, they can eng
 age in multivalent ‘cohesive’ interactions to form the so-called FG ph
 ase\, which acts as a permeability barrier within the central NPC channel.
  This FG phase repels inert macromolecules\, preventing mixing of nuclear 
 and cytoplasmic contents. At the same time\, it is an excellent 'solvent' 
 for NTRs\, allowing them to pass rapidly with their cargo.\n\nThe lecture 
 will focus on the assembly\, properties and transport selectivity of the F
 G phase. It will address what ‘cohesive’ interactions are\, which feat
 ures of a mobile species encode a rapid or a slow pore-passage\, how RNAs 
 and ribosomal subunits are transported\, and how the giant capsid of HIV c
 an traverse nuclear pores and deliver the viral genome into the nucleus.\n
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) 
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