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SUMMARY:Claudia Ribeiro Almeida\, Group Leader\, Babraham Institute - Clau
 dia Ribeiro Almeida\, Group Leader\, Babraham Institute
DTSTART:20260423T150000Z
DTEND:20260423T160000Z
UID:TALK240628@talks.cam.ac.uk
CONTACT:Liat Churley
DESCRIPTION:This Cambridge Immunology Network Seminar will take place on *
 Thursday 23rd April 2026*\, starting at *4:00pm*\, in the Ground Floor Lec
 ture Theatre\, Jeffrey Cheah Biomedical Centre (JCBC)\n\n*Speaker*: Claudi
 a Ribeiro Almeida\, Group Leader\, Babraham Institute\n\n*Title*: "RNA-Med
 iated Regulation of Germinal Centre B-Cell Fitness: a tale of two DEAD-box
  RNA helicases"\n\n*Abstract*: Effective humoral immunity relies on the cl
 onal expansion of antigen specific B-cells and the generation of high affi
 nity antibodies within germinal centres. However\, how B-cells sustain the
  anabolic demands imposed by antigen-driven proliferation is incompletely 
 understood. Our studies focus on the role of DEAD-box RNA helicases\, a gr
 oup of RNA remodelling enzymes that collectively control every step of the
  mRNA life cycle. I will discuss our findings on the RNA helicases DDX1 an
 d DDX3X\, that together uncover a critical requirement for heightened prot
 ein synthesis during B-cell positive selection in germinal centres. This w
 ork identifies fundamental mechanisms underpinning germinal centre B-cell 
 fitness that could be actioned for therapeutic purpose. \n\n*Host*: Georg 
 Petaku\, Babraham Institute\, Cambridge\n\nRefreshments will be available 
 following the seminar.
LOCATION: Lecture Theatre\, Jeffrey Cheah Biomedical Centre\, Cambridge Bi
 omedical Campus
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