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SUMMARY:Neural basis of decision making - Guillaume Hennequin ( University
  of Cambridge)\; Robert Crossen
DTSTART:20251111T131500Z
DTEND:20251111T124500Z
UID:TALK240745@talks.cam.ac.uk
CONTACT:124819
DESCRIPTION:We will present two recent studies from the Brody lab explorin
 g the neural dynamics underlying perceptual decision-making and commitment
 . Luo et al. (2025) used large-scale neural recordings and data-driven mod
 elling to reveal that during auditory evidence accumulation\, cortical and
  striatal population activity transitions between two distinct dynamical r
 egimes—an early\, input-driven phase and a later\, autonomous phase mark
 ing decision commitment. Building on this\, Bondy et al. (2025) examined b
 rain-wide recordings across up to twenty regions\, showing that decision s
 ignals and inferred commitment times co-fluctuate across the brain along a
  single dominant dimension\, originating in a frontal–striatal subnetwor
 k and propagating globally. Together\, these studies provide a compelling 
 multi-scale view of how local and distributed neural dynamics give rise to
  coherent\, brain-wide decision processes.\n\nReferences:\nLuo\, T. Z.\, K
 im\, T. D.\, Gupta\, D.\, Bondy\, A. G.\, Kopec\, C. D.\, Elliott\, V. A.\
 , DePasquale\, B. & Brody\, C. D. (2025). Transitions in dynamical regime 
 and neural mode during perceptual decisions. Nature\, 646\, 1156–1166. h
 ttps://www.nature.com/articles/s41586-025-09528-4\nBondy\, A. G.\, Charlto
 n\, J. A.\, Luo\, T. Z.\, Kopec\, C. D.\, Stagnaro\, W. M.\, Venditto\, S.
  J. C.\, Lynch\, L.\, Janarthanan\, S.\, Oline\, S. N.\, Harris\, T. D. & 
 Brody\, C. D. (2025). Brain-wide coordination of decision formation and co
 mmitment. bioRxiv. https://www.biorxiv.org/content/10.1101/2024.08.21.6090
 44v5
LOCATION:CBL Seminar Room\, Engineering Department\, 4th floor Baker build
 ing
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