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SUMMARY: Introducing BoltzGen: Toward Universal Binder Design - Hannes St
 ärk\, PhD student at MIT
DTSTART:20251118T150000Z
DTEND:20251118T160000Z
UID:TALK240835@talks.cam.ac.uk
CONTACT:Pietro Lio
DESCRIPTION:    BoltzGen is a new generative model for designing protein a
 nd peptides of any modality to bind a wide range of biomolecular targets.\
 n    It unifies design and structure prediction\, resulting in a single mo
 del that also achieves state-of-the-art folding performance. BoltzGen’s 
 generation process can be controlled with a flexible design specification 
 language over covalent bonds\, structure constraints\, binding sites\, and
  more.\n    BoltzGen was developed at MIT and experimentally validated in 
 a large-scale distributed effort involving multiple academic and industry 
 labs. These groups independently validated designed nanobodies\, minibinde
 rs\, peptides\, and cyclic peptides against diverse and novel targets such
  as small molecules\, peptides\, and proteins with disordered regions\, wi
 th robust experimental validation including functional readouts in live ce
 lls.\n    We explicitly focus our experimental validation on targets that 
 are highly dissimilar to any proteins for which bound structures exist - m
 ore faithfully mirroring a real discovery campaign. \n    BoltzGen\, like 
 Boltz-1 and Boltz-2\, is open source under MIT license and freely availabl
 e for unrestricted academic and commercial use\, including data\, model we
 ights\, training\, and inference code.\n\nhttps://github.com/HannesStark/b
 oltzgen\n
LOCATION:Computer Laboratory\, William Gates Building\, Lecture Theatre 1
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