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SUMMARY:Poster Flash Talks Group B: Regulation of ultradian pulsatility an
 d stress responses in the human HPA axis - Belinda Lombard (University of 
 Birmingham)
DTSTART:20251203T143000Z
DTEND:20251203T143500Z
UID:TALK241099@talks.cam.ac.uk
DESCRIPTION:The hypothalamic-pituitary-adrenal (HPA) axis is the endocrine
  system controlling dynamic responses to stressors. Mathematical modelling
  and experiments in rodents have shown that negative feedback loops underp
 in rhythmic activity within this axis\, but a human equivalent model is la
 cking. This talk outlines a data-driven approach to calibrate a model of h
 ormonal rhythms in the human HPA axis. The model is written in terms of De
 lay Differential Equations (DDEs) and predicts the conditions that lead to
  pulsatile secretion of cortisol and ACTH hormones with ultradian.
LOCATION:Seminar Room 1\, Newton Institute
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