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SUMMARY:LMB Seminar - Mechanisms of mRNA packaging and export - Clemens Pl
 aschka\, Research Institute of Molecular Pathology\, Vienna
DTSTART:20260427T100000Z
DTEND:20260427T110000Z
UID:TALK241201@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The nuclear export of messenger RNA mRNA is a key step in euka
 ryotic gene expression. Despite recent insights into the nuclear packaging
  of human mRNAs into ribonucleoprotein complexes (mRNPs)\, the subsequent 
 molecular events that govern mRNA export are poorly understood. Here\, I w
 ill present our recent structural\, biochemical\, and genetic data on how 
 human mRNAs are prepared for their nuclear export and quality controlled. 
 This pathway involves the recognition and remodeling of mRNPs by the trans
 cription-export complexes (TREX)\, the formation of export-competent mRNPs
 \, the docking of mRNPs at the nuclear pore complex (NPC)\, and the releas
 e of mRNPs at the NPC to initiate export. Our biochemical and structural d
 ata uncover the ATPase DDX39/UAP56 as a central molecular switch that dire
 cts mRNPs through TREX and the NPC-anchored TREX-2 complex using its ATPas
 e and mRNA-binding cycle. Finally\, we discover a paralogous complex to TR
 EX-2\, which directs mRNPs towards decay instead of export. Our combined f
 indings provide insights into the packaging and export of mRNA and its qua
 lity control.
LOCATION:In person in the Max Perutz Lecture Theatre (CB2 0QH) 
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