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SUMMARY:Alkis Seraphim Lecture 2025: Mutate Everything! Mapping the energe
 tic and allosteric structures of proteins at scale - Professor Ben Lehner\
 , Head of Generative and Synthetic Genomics at the Wellcome Sanger Institu
 te 
DTSTART:20251204T163000Z
DTEND:20251204T173000Z
UID:TALK241213@talks.cam.ac.uk
CONTACT:Francis Neary
DESCRIPTION:*Please Book Here*: https://www.eventbrite.com/e/alkis-seraphi
 m-lecture-2025-professor-ben-lehner-tickets-1869749433889?aff=TC\n\nAll we
 lcome\; followed by a drinks reception at 5.30pm in the Whale Café\, Univ
 ersity Museum of Zoology\n\nBen Lehner's research is currently focussed on
  using massively parallel synthesis/selection/sequencing experiments and m
 achine learning to quantify\, understand and predict sequence-to-activity 
 (especially the biophysical properties of macromolecules) at scale\, inclu
 ding protein stability\, aggregation\, affinity\, specificity\, allostery\
 , and mRNA splicing and regulation. Previous research has addressed founda
 tional questions in genetics\, including why genetically-identical individ
 uals are not identical\, how the physiology and environment of one generat
 ion alters subsequent generations\, why mutations occur at different rates
  in different genes\, and how mutations interact to alter the activities o
 f molecules and the characteristics of individuals.\n\nHis research has be
 en recognised by multiple prizes\, including the Bettencourt Prize for Lif
 e Sciences\, the Eppendorf Award\, the Balfour Prize\, and the EMBO Gold M
 edal. Ben is a Fellow of the Academy of Medical Sciences and a Fellow of t
 he Royal Society.
LOCATION:Babbage Lecture Theatre\, New Museums Site\, Pembroke Street\, Ca
 mbridge CB2 3QF
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