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SUMMARY:Re-Analysis of Three Network Meta-Analyses of Fluoxetine for Depre
 ssion in Children and Adolescents: Clarifying Efficacy and Finding a Zombi
 e - Dr Martin Plöderl\, Dr Florian Naudet\, and Dr Richard Lyus
DTSTART:20260226T123000Z
DTEND:20260226T133000Z
UID:TALK241405@talks.cam.ac.uk
CONTACT:Oliver Knight
DESCRIPTION:Fluoxetine is recommended as the first-line medication for the
  treatment of depression in children and young people\, typically based on
  the results of three network meta-analyses (NMAs) published in the last d
 ecade. However\, two of these NMAs\, published in Lancet journals\, report
 ed a moderate effect (SMD 0.5) with very low certainty\; while the third\,
  published by Cochrane\, reported a small effect (SMD 0.2) with moderate c
 ertainty\, which fell within the authors’ predetermined range of equival
 ence with placebo. The findings of the Lancet NMA might support the cautio
 us use of fluoxetine\, but the findings of the Cochrane NMA do not. We sou
 ght to explain this discrepancy.
LOCATION:Online via zoom
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