BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Margot Smit: Arrested Development: temporal regulation of cell ide
 ntity during plant embryogenesis\; Susan Wopat: The zebrafish gastrula is 
 shaped by stationary and germ layer–specific tissue flows - Margot Smit\
 , Susan Wopat
DTSTART:20260126T143000Z
DTEND:20260126T153000Z
UID:TALK241591@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Name:  Margot Smit  \nAffiliation: ZMBP\, Tuebingen University
 \, Germany \n\nTitle: Arrested Development: temporal regulation of cell id
 entity during plant embryogenesis \n\nAbstract: \n\nMulticellularity allow
 s organisms such as plants to form complex structures but these need to be
  carefully controlled in both space and time. What determines the relative
  timing of cell fate acquisition\, progression\, and differentiation along
  a cellular trajectory\, and when/how is development slowed down or sped u
 p? In our group\, we investigate the mechanisms the plant uses to control 
 the timing of two main cell fate transitions in the embryo: stomatal fate 
 acquisition and differentiation. \n\nStomatal fate acquisition during embr
 yogenesis is delayed: The stomatal initiator SPCH is present as soon as th
 e embryonic cotyledon epidermis exists but does not induce stomatal fate a
 cquisition for several days. This delay does not exist after germination: 
 both in true leaves and in expanding cotyledons SPCH induces stomatal fate
  acquisition on the scale of hours rather than days. These findings indica
 te that currently unknown factors prevent initial stomatal lineage progres
 sion in the embryo. We are studying how stomatal regulation is differently
  wired during embryogenesis. \n\nIn addition to fate acquisition\, stomata
 l differentiation is also delayed during embryogenesis. No cell types diff
 erentiate in the Arabidopsis embryo\, but I found that factors that normal
 ly drive stomatal differentiation cannot do so during embryogenesis. We ha
 ve now identified several mutants where stomatal cells undergo either full
  or partial differentiation and are trying to understand the underlying me
 chanisms responsible. \n\n\nTALK 2 \nName:  Susan Wopat \n\nAffiliation: U
 C Santa Barbara\, CA\, USA \n\nTitle: The zebrafish gastrula is shaped by 
 stationary and germ layer–specific tissue flows \n\nAbstract:  \n\nDurin
 g gastrulation\, cells collectively move to transform the blastula into a 
 multilayered embryo. While genetic signaling pathways that establish body 
 axes and cell fates are well characterized\, how these programs coordinate
  the motion of tens of thousands of cells in vertebrate embryos remains un
 clear. To address this\, we combine in toto live imaging\, tissue-specific
  markers\, and quantitative analyses to study germ layer dynamics in zebra
 fish embryos. By applying a user-friendly tissue cartography pipeline\, we
  computationally separate the enveloping layer (EVL)\, epiblast\, and meso
 derm to analyze global shapes and cell flows in a tissue-specific manner. 
 Examining tissues individually shows that each layer exhibits distinct\, h
 ours-long flow configurations that remain remarkably stable over time. Thi
 s suggests that a sequence of stationary tissue flow modules transports ce
 lls to their destinations to build the unique tissue morphologies of the z
 ebrafish gastrula. Mathematical decomposition further suggests that epibla
 st flow is strongly influenced by a superposition of convergent flow in th
 e mesoderm and expansion flow in the EVL. Together\, these results indicat
 e that\, despite the molecular complexity of development\, vertebrate gast
 rulation is governed by emergent simplicity arising from robust physical p
 rinciples\, setting the stage for linking genetic signaling to tissue-scal
 e dynamics. 
LOCATION:Online
END:VEVENT
END:VCALENDAR