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SUMMARY:Molecular and cellular scale symmetry breaking in planar polarity 
 (or why the hairs all point the same way on the wing of a fly) - David Str
 utt\, School of Biosciences\, University of Sheffield\, UK
DTSTART:20260202T143000Z
DTEND:20260202T153000Z
UID:TALK241594@talks.cam.ac.uk
CONTACT:Jia CHEN
DESCRIPTION:Abstract:  \n\nPlanar polarity refers to the ability of struct
 ures in a developing tissue to adopt a common polarity and is a universal 
 phenomenon in plant and animal morphogenesis. The best-studied molecular s
 ystem that defines planar polarity in animal tissues is the Frizzled-depen
 dent ‘core’ planar polarity pathway. This pathway functions by forming
  asymmetric intercellular protein complexes between neighbouring cells\, w
 ith the polarity of these complexes having a constant orientation relative
  to the plane of the tissue. \n\nThe establishment of core pathway planar 
 polarity requires symmetry breaking at multiple levels. The first is estab
 lishing asymmetry within the intercellular complexes\, the second is polar
 isation of complexes within individual cell junctions and cells\, and the 
 third is orienting polarity relative to the axes of the tissue. Ongoing wo
 rk in the lab seeks to understand each of these steps and how they are int
 egrated to produce a uniform pattern of planar polarity\, using the Drosop
 hila pupal wing as a model experimental system.  
LOCATION:In person@Hodgkin Huxley room PDN and online
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