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SUMMARY:Biological lessons from presurgical studies of breast cancer - Mit
 ch Dowsett\, Institute of Cancer Research\, Royal Marsden Hospital
DTSTART:20101021T120000Z
DTEND:20101021T130000Z
UID:TALK24177@talks.cam.ac.uk
CONTACT:Kate Davenport
DESCRIPTION:Presurgical treatment of breast cancer provides a unique oppor
 tunity to link biology and clinical variables as well as becoming an attra
 ctive scenario for drug development. We have \nvalidated the proliferation
  marker\, Ki67\, as an intermediate end-point of efficacy for endocrine th
 erapy as early as 2 weeks after starting treatment. A variety of immunohis
 tochemical and genomic analyses have enabled us to make several novel biol
 ogical observations including on a new index of oestrogen regulated genes 
 (AvERG)\, the coordinated expression of genes adjacent to ESR1 and the clo
 se relationship between hypoxia and proliferation. In each circumstance it
  has become clear that the extreme heterogeneity of ER+ breast cancer requ
 ires large numbers of correlative data for confident definition of associa
 ted factors and subgroup. To enable this we have recruited over 900 patien
 ts with ER+ breast cancer to the PeriOperative Endocrine Therapy for Indiv
 idualising Care (POETIC) trial of presurgical aromatase inhibitor treatmen
 t. Total recruitment will be 4\,000 and will provide an opportunity to mar
 kedly enhance our understanding of ER+ breast cancer in patients.\n\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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