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SUMMARY:Interested in Catalysis ?  Biology sets ultimate goals\, from elec
 trocatalysts to tandem++ cascades in mesoporous materials - Professor Fras
 er A. Armstrong FRS\, University of Oxford
DTSTART:20260130T140000Z
DTEND:20260130T150000Z
UID:TALK241921@talks.cam.ac.uk
CONTACT:Sharon Connor
DESCRIPTION:Oxidation and reduction reactions are fundamental to all livin
 g organisms\, which must extract and process energy from different sources
 .    This lecture will begin by outlining the early discovery and subseque
 nt development of enzymes as extremely efficient (virtually reversible in 
 the Nernstian sense) electrocatalysts\, suggesting that minimising overpot
 ential (electrochemical activation energy) would have been a driving facto
 r in early evolution.  \nThe lecture will continue with the concept of the
  Electrochemical Leaf (e-Leaf)\, a unique platform for biocatalysis that i
 nvolves the nanoconfinement of complex enzyme cascades (to achieve tandem+
 + catalysis) in mesoporous electrode materials\, with interactive energiza
 tion and control via electrochemically reversible NAD(P)(H) recycling.   T
 he tight channelling of cascade intermediates opens up electrochemistry to
  all classes of enzymes\, since cascade intermediates now become current c
 arriers. The e-Leaf can be exploited for lego-style biosensing and product
 ion of complex compounds including pharmaceuticals.    It enables studies 
 of the collective action of enzymes that are concentrated in enclosures an
 d which\, through their high selectivities and activities\, can become ana
 logous to the logic gates of electronic circuits.  The outcome - ‘cascad
 etronics’ – has implications for how living cells operate.\n\nSome rel
 evant papers. \n\nDiode-like Behaviour of a Mitochondrial Electron-transpo
 rt Enzyme. \nA. Sucheta\, B. A. C. Ackrell\, B. Cochran and F. A. Armstron
 g.  Nature 356\, 361-362 (1992).\n\nReversibility and Efficiency in Electr
 ocatalytic Energy Conversion and Lessons from Enzymes.  \nF. A. Armstrong 
 and J. Hirst. Proc. Natl. Acad. Sci. USA 108\, 14049-14054 (2011). \n\nMec
 hanism of Hydrogen Activation by [NiFe]-hydrogenases.  \nR. M. Evans\, E. 
 J. Brooke\, S. A. M. Wehlin\, E. Nomerotskaia\, F. Sargent\, S. B. Carr\, 
 S. E. V. Phillips and F. A. Armstrong. Nature Chem. Biol. 12\, 46-50 (2016
 ).\n\nFrom Protein Film Electrochemistry to Nanoconfined Enzyme Cascades a
 nd the Electrochemical Leaf.  \nF. A. Armstrong\, B. Cheng\, R. A. Herold\
 , C. F. Megarity and Bhavin Siritanaratkul.  Chem. Rev.  123\, 5421–5458
  (2023)\,  \n\nReplacing a Cysteine Ligand by Selenocysteine in a [NiFe]-H
 ydrogenase Unlocks Hydrogen Production Activity and Addresses the Role of 
 Concerted Proton-Coupled Electron Transfer in Electrocatalytic Reversibili
 ty.  \nR. M. Evans\, N. Krahn\, J. Weiss\, K. A. Vincent\, D. Söll and F.
  A. Armstrong.   J. Amer. Chem. Soc. 146\, 16971-16976 (2024).\n\nInteract
 ive Biocatalysis Achieved by Driving Enzyme Cascades inside a Porous Condu
 cting Material.  \nB. Siritanaratkul\, C. F. Megarity\, R. A. Herold and F
 . A. Armstrong.  Communications Chemistry\, 7: 132 (2024).  \n\nBuilding L
 ocalized NADP(H) Recycling Circuits to Advance Enzyme Cascadetronics.\nR. 
 A. Herold\, C. J. Schofield and F. A. Armstrong. Angewandte Chemie. Int. E
 d.\, 64\, e202414176 (2025).\n
LOCATION:Dept of Chemistry\, Wolfson Lecture Theatre 
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