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SUMMARY:How to build a contact site? The molecular mechanism of on-demand
  sterol biosynthesis at organelle contact sites - Maya Schuldiner - Weizma
 nn Institute
DTSTART:20260205T150000Z
DTEND:20260205T160000Z
UID:TALK242278@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Contact sites are specialized zones of proximity between organ
 elles\, essential for communication and coordination. The formation of End
 oplasmic Reticulum (ER) contact sites\, relies on a unique membrane enviro
 nment enriched in sterols. However\, how these sterol-rich domains are for
 med and maintained was unclear. We found that the yeast membrane protein Y
 et3\, homolog of human BAP31\, localizes to multiple ER contacts. We show 
 that Yet3 interacts with the post-squalene ergosterol biosynthesis enzymes
  through its transmembrane domains. Yet3 recruits the enzymes to create st
 erol-rich environments. Increasing sterols at ER contacts causes their dep
 letion from the plasma membrane\, leading to a compensatory reaction and a
 ltered cell metabolism. We demonstrate that the molecular function of Yet3
  and BAP31 is conserved. Our data shows that Yet3 and BAP31 provide on-dem
 and sterols at contacts thus shaping organellar structure and function. Th
 is molecular understanding provides new insights into the role of BAP31 in
  development and pathology.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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