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SUMMARY:&quot\;Life-s first kiss – what do we miss?&quot\; - Andrea Paul
 i - IMP
DTSTART:20260305T150000Z
DTEND:20260305T160000Z
UID:TALK242281@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Life of sexually reproducing organisms starts with the fusion 
 of two highly specialized cells\, the egg and the sperm\, which gives rise
  to a single cell\, the zygote. Fertilization initiates the egg-to-embryo 
 transition\, one of the most dramatic developmental transition resulting i
 n the transformation of the egg from a dormant state into regulatorily and
  functionally distinct embryonic cells. While this transition has been stu
 died extensively in respect to zygotic genome activation\, the molecular m
 echanisms that regulate the maintenance of dormancy in the egg and mediate
  sperm-egg binding and fusion during fertilization remain poorly understoo
 d. The vision of the Pauli lab is to gain mechanistic insights into the eg
 g-to-embryo transition\, with a specific focus on the molecular control of
  fertilization and developmentally programmed dormancy and re-activation. 
 In her seminar\, Andi will talk about recent findings from her lab towards
  uncovering the mechanism of vertebrate fertilization and translational re
 gulation during the egg-to-embryo transition. By combining genetic\, molec
 ular\, cellular\, biochemical\, structural and genomics approaches in vivo
  and in vitro\, the Pauli lab aims to reveal new concepts and molecular me
 chanisms governing this fascinating developmental transition that marks th
 e beginning of lif
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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