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SUMMARY:Drugging the Gut Microbiome: From Unintended Side Effects to Targe
 ted Modulation - Prof. Dr. Lisa Maier- University Hospital Tübingen
DTSTART:20260319T150000Z
DTEND:20260319T160000Z
UID:TALK242677@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:Drugs\, including both antibiotics and non-antibiotic compound
 s\, are among the strongest factors shaping interindividual differences in
  the composition of the human gut microbiome. While the microbiome-disrupt
 ing effects of antibiotics are well documented\, the impact of non-antibio
 tic drugs remains poorly understood\, particularly in terms of their conse
 quences for host health.\n\nIn this talk\, I will discuss how drug-induced
  microbiome alterations influence susceptibility to exogenous and ectopic 
 pathogen colonization. Using high-throughput cultivation of gut microbes i
 n monocultures and communities\, gnotobiotic mouse models\, and human coho
 rt studies\, we show that exposure to specific non-antibiotic drugs can pr
 omote pathogen colonization and increase infection risk.\n\nHowever\, the 
 ability of drugs to modulate the microbiome can also be leveraged for ther
 apeutic benefit. I will present our strategies for identifying compounds t
 hat counteract ectopic colonization by oropharyngeal species\, restoring a
  healthy microbial balance both in vitro and in mouse models.\n\nThese fin
 dings highlight both the risks and potential therapeutic applications of d
 rug-microbiome interactions\, opening new avenues for targeted microbiome 
 modulation in clinical settings.
LOCATION:Jean Thomas Lecture theatre\, Sanger Building\, Tennis Court Road
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