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SUMMARY: Flexible Use of Limited Resources for Sequence Working Memory in 
 Macaque Prefrontal Cortex - Paul Bays
DTSTART:20260109T140000Z
DTEND:20260109T150000Z
UID:TALK242752@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a very recent paper by Li
  and colleagues (2025).\n\nAbstract: “Our brain is remarkably limited in
  how many items it can hold simultaneously\, but it can also represent unb
 ounded novel items through generalization. How the brain rationally uses l
 imited resources in working memory (WM) remains unexplored. We investigate
 d mechanisms of WM resource allocation using calcium imaging and electroph
 ysiological recording in the prefrontal cortex of monkeys performing seque
 nce WM (SWM) tasks. We found that changes in the neural representation of 
 SWM\, including geometry\, generalizable and separate rank subspaces\, ref
 lected WM load. SWM resources\, represented by neurons’ signal strength 
 and spatial tuning projected onto each rank subspace\, were shared flexibl
 y between ranks. Crucially\, the prefrontal cortex dynamically utilized sh
 ared tuning neurons to ensure generalization\, while engaging disjoint and
  spatially shifted neurons to minimize interference\, thus achieving a tra
 de-off between behavioral and neural costs within capacity. The allocated 
 resources can predict monkeys’ behavior. Thus\, the geometry of composit
 ionality underlies the flexible use of limited resources in SWM” (Li et 
 al.\, 2025).\n\nReference: Li\, S.\, Chen\, J.\, Zhang\, C.\, Tang\, S.\, 
 Xie\, Y.\, & Wang\, L. (2025). Flexible Use of Limited Resources for Seque
 nce Working Memory in Macaque Prefrontal Cortex. Nature Communications\, 1
 6(1)\, 10386. https://doi.org/10.1038/s41467-025-65380-0
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
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