BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The patterns and temporal dynamics of genomic instability in metas
 tatic pancreatic cancer - Peter Campbell\, Wellcome Trust Sanger Institute
DTSTART:20100514T093000Z
DTEND:20100514T103000Z
UID:TALK24319@talks.cam.ac.uk
CONTACT:Katrien Van Look
DESCRIPTION:Human cancers are characterised by markedly disordered genomic
  architecture\, driven by genomic instability. We harnessed advances in DN
 A sequencing to annotate genomic rearrangements in 13 patients with pancre
 atic cancer and explore clonal relationships among metastases. We find tha
 t pancreatic cancer\, unlike breast cancer\, acquires rearrangements indic
 ative of telomere dysfunction and abnormal cell-cycle control\, namely dys
 regulated G1-S phase transition with intact G2-M checkpoint. These occurre
 d early in cancer development and initiated amplification of cancer genes.
  Genomic instability frequently continued after cancer dissemination\, res
 ulting in on-going\, parallel and even convergent evolution among differen
 t metastases. We find evidence that secondary metastases can themselves se
 ed tertiary metastases\; initiating metastasis may require mutations beyon
 d those required for primary tumours\; and phylogenetic trees across metas
 tases show organ-specific branches. These data attest to the richness of g
 enetic variation in cancer\, hewn by the tandem forces of genomic instabil
 ity and evolutionary selection.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
END:VEVENT
END:VCALENDAR