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SUMMARY:Epigenetic inheritance of chromatin states in C. elegans - Prof. F
 lorian Steiner - University of Geneva
DTSTART:20260127T160000Z
DTEND:20260127T170000Z
UID:TALK243724@talks.cam.ac.uk
CONTACT:90994
DESCRIPTION:The ability to replicate and pass information to descendants i
 s a fundamental requirement for life. In addition to the DNA-based genetic
  information\, modifications of the DNA or DNA-associated proteins can cre
 ate patterns of heritable genome regulation. We study how such chromatin-b
 ased information is passed from one generation using the model organism C.
  elegans. I will present two case studies: the centromere-specific histone
  variant CENP-A\, and H3K27me3\, a conserved histone posttranslational mod
 ification associated with gene repression. We found that patterns of CENP-
 A incorporation persist for one generation before they are reset. In contr
 ast\, we found that induced alterations of the genome-wide H3K27me3 landsc
 ape and the associated fertility defects persist for many generations in g
 enetically wildtype descendants under selective pressure. I will discuss o
 ur research to uncover the mechanisms underlying these cases of epigenetic
  inheritance.
LOCATION:Department of Biochemistry\, Sanger Building\, Jean Thomas Lectur
 e Theatre
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