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SUMMARY:The Biology of Profound Autism: From Embryogenesis to Social Neura
 l and Clinical Outcomes by Pre-School Ages  - Professor Eric Courchesne\, 
 University of California\, San Diego
DTSTART:20260204T160000Z
DTEND:20260204T170000Z
UID:TALK244258@talks.cam.ac.uk
CONTACT:Simon Braschi
DESCRIPTION:Autism biology is present by the first month of pregnancy\, an
 d biological differences between profound and mild autism are likewise pre
 sent at that time.  In within-child designs\, profound autism biology begi
 ns with accelerated and excessive cell proliferation that leads to overgro
 wth of cortical brain organoids (BCO)\, cell stress and DNA damage\, alter
 ed neurogenesis\, reduced axon sprouting\, deviant cell migration\, reduce
 d spontaneous neural activity\, reduced synaptogenesis\, and reduced compl
 exity of neural firing patterns. These profound autism embryonic differenc
 es are statistically correlated with and related to severe social symptom 
 severity\; reduced social attention\, adaptive behavior level\, IQ\, langu
 age and social neural activity\; increased overgrowth of social cortex by 
 about 2 years of age. For example\, more embryonic BCO overgrowth is corre
 lated with more the severe social symptoms by age 2. More excess of cells 
 generated is correlated with greater early brain overgrowth by age 2. More
  reduced the neural firing patterns is correlated with more reduced adapti
 ve behavior abilities. Thus\, profound autism is caused by progressive\, m
 ulti-stage\, multi-process pathobiology beginning in the first month of pr
 egnancy and leading to reduced social neural activity\, social attention\,
  adaptive behavior and severe social symptoms. This knowledge of profound 
 autism embryonic relationships with outcome clinical and neural patterns h
 as emerged from within-child iPSC research designs. Profound autism is not
  a mystery\, nor is it an intractable hodgepodge of different pathobiologi
 es in different children. Instead\, it is knowable and identifiable at ear
 ly ages when treatment can begin.
LOCATION:https://us02web.zoom.us/j/81074736811?pwd=wGWdPzaQKPkbBPqrdFgk4o1
 mkITSyV.1
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