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SUMMARY:The genetic architecture of autism: from medicine to neurodiversit
 y  - Prof. Thomas Bourgeron\, Université Paris Cité\, Institut Pasteur\,
  
DTSTART:20260218T113000Z
DTEND:20260218T123000Z
UID:TALK244789@talks.cam.ac.uk
CONTACT:Simon Braschi
DESCRIPTION:The genetic contribution to autism is high (>80% of heritabili
 ty)\, but its architecture involves a complex combination of rare and comm
 on variants. Autism shares genetic variations with other conditions such a
 s attention deficit hyperactivity disorders (ADHD)\, intellectual disabili
 ty\, and epilepsy\, but little is known about the factors that contribute 
 to the diversity of the clinical trajectories. In this presentation\, I wi
 ll introduce recent results that shed new light on the inheritance of auti
 sm and on some of the underlying mechanisms. For example\, I will illustra
 te how genes associated with autism shape brain anatomy and connectivity b
 y regulating gene expression and synaptic function. Finally\, I will prese
 nt how the R2D2-MH project (Risk\, Resilience and Developmental Diversity 
 in Mental Health) is using participatory research to understand why some c
 arriers of genetic variants seem to be protected from adverse symptoms whi
 le others have more difficulties to thrive in the society. In summary\, th
 is integrated and participatory research aims to provide each person with 
 the assessments\, treatments\, and accommodations their specific neurodeve
 lopmental profile requires.
LOCATION: https://us02web.zoom.us/j/81286610099?pwd=HsKTIo1MzZ7eEOJUaVYrEB
 bCvSSW1g.1
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