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SUMMARY:Catalytic Transfer Reactions of Non-Stabilized Carbenes - Purdue U
 niversity
DTSTART:20260316T143000Z
DTEND:20260316T160000Z
UID:TALK244885@talks.cam.ac.uk
CONTACT:Dr Matthew Gaunt
DESCRIPTION:Carbenes are versatile reactive intermediates that display ort
 hogonal reactivity to common nucleophilic and electrophilic functional gro
 ups. Catalytic carbene transfer reactions were first discovered over a cen
 tury ago\, and numerous examples of [n + 1]-cycloaddition reactions have s
 ince been developed\, often with control over diastereo- and enanatioselec
 tivity. Most of these reactions rely on the controlled decomposition of di
 azoalkanes as a central strategy to access reactive carbene equivalents.\n
 \nDespite the utility of diazoalkanes in organic synthesis\, they are inhe
 rently limited by the need for stabilizing substituents such as aryl or ca
 rbonyl groups. In order to develop transfer reactions of nonstabilized car
 benes\, it is necessary to consider an alternative set of precursors. Our 
 group has shown that nickel and cobalt catalysts can promote reductive [n 
 + 1]-cycloaddition reactions using readily available and indefinitely stab
 le 1\,1-dichloroalkanes and 1\,1-dichloroalkenes as precusors for carbenes
  and vinylidenes\, respectively. In this seminar\, I will describe our dev
 elopment of new cycloaddition methods and our current hypotheses about the
  mechanisms of these reactions.
LOCATION:Dept of Chemistry\, Wolfson Lecture Theatre 
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