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SUMMARY:CLRs and TLRs in anti-fungal immunity - Professor Gordon Brown\, I
 nstitute of Medical Sciences\, University of Aberdeen
DTSTART:20100512T153000Z
DTEND:20100512T163000Z
UID:TALK24504@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:The innate ability to detect pathogens is essential for multic
 ellular existence\, and has been achieved through the evolution of germ-li
 ne encoded receptors which can recognise non-self structures\, the so-call
 ed "pattern recognition receptors" (PRR). In fungal infections\, the Toll-
 like receptors (TLRs) and C-type lectin receptors (CLRs) are the main PRR 
 which drive protective immune responses. In this presentation\, I will rev
 iew our current understanding of the functions and role of Dectin-1 (the a
 rchetypical lectin PRR )\, and other CLRs\, and will explore how the colla
 boration between TLRs and CLRs is essential for protective anti-fungal imm
 unity.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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