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SUMMARY:Adapting to unfolded protein load in the endoplasmic reticulum - P
 rof. David Ron (University of Cambridge)
DTSTART:20100421T093000Z
DTEND:20100421T103000Z
UID:TALK24531@talks.cam.ac.uk
CONTACT:8272
DESCRIPTION:In this talk some of the principles thought to govern the sens
 ing of the misfolded/unfolded protein load in the ER and the transcription
 al and translational response to that load (referred to collectively as th
 e unfolded protein response or UPR) will be described. This focus on the p
 hysiology of the system will aim to justify the interest in manipulating i
 t to therapeutic ends. Towards the close of the talk\, an example of nasce
 nt attempts to manipulate the UPR will be discussed.
LOCATION:Wolfson Lecture Theatre\, Unilever Centre\, Department of Chemist
 ry
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