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SUMMARY:NMR studies of a helical 7-transmembrane receptor - Dr. Daniel Nie
 tlispach (University of Cambridge)
DTSTART:20100505T093000Z
DTEND:20100505T103000Z
UID:TALK24532@talks.cam.ac.uk
CONTACT:8272
DESCRIPTION:The study of seven-helical integral membrane proteins (7TM) re
 mains a challenge for structural biology. We use the 7TM phototaxis recept
 or sensory rhodopsin pSRII to demonstrate the feasibility of such studies 
 by means of solution NMR spectroscopy. For the first time we present the f
 ull 3D structure determination of a 7TM receptor using NMR spectroscopy. T
 he size of the protein-detergent micelle complex under investigation is on
  the order of 70 kDa. The quality of the pSRII structure ensemble is extre
 mely good (backbone root mean squared deviation of 0.48 Å). Based on what
  we have learnt with pSRII we attempt to discuss the chances for the succe
 ss of similar NMR structural studies with other 7TM proteins.
LOCATION:Unilever Lecture Theatre\, Unilever Centre\, Department of Chemis
 try
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