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SUMMARY:Hippocampal neuronal activity is aligned with action plans - Chang
 min Yu
DTSTART:20260326T090000Z
DTEND:20260326T110000Z
UID:TALK246070@talks.cam.ac.uk
CONTACT:124819
DESCRIPTION:Neuronal firing in the hippocampus has long been associated wi
 th diverse variables such as spatial location\, time\, sensory cues\, rewa
 rds and motor actions. However\, it has remained unclear whether these cor
 relations reflect multiple distinct functions of hippocampal circuits or a
  more unified computational principle. In this work\, researchers develope
 d a behavioral paradigm in mice where spatial\, auditory and reward cues w
 ere independently manipulated to vary their relevance. High‑density elec
 trophysiological recordings across hippocampal ensembles revealed tuning t
 o each modality. Crucially\, by comparing animals’ movement trajectories
  and action sequences\, the authors show that hippocampal spiking is more 
 strongly aligned with internally generated action plans than with external
  sensory variables per se. Furthermore\, this action‑aligned activity wa
 s modulated by uncertainty about the goal\, suggesting that hippocampal re
 presentations reflect ongoing deliberative planning processes. Overall\, t
 hese results support a model in which internally generated hippocampal seq
 uences are selected and updated according to the animal’s planned action
 s toward goals\, and apparent tuning to external variables may arise becau
 se those variables correlate with action progression rather than being dir
 ectly encoded.\n\nReference: Zutshi\, I.\, Apostolelli\, A.\, Yang\, W.\, 
 Zheng\, Z. S.\, Dohi\, T.\, Balzani\, E.\, ... & Buzsáki\, G. (2025). Hip
 pocampal neuronal activity is aligned with action plans. Nature\, 639(8053
 )\, 153-161.
LOCATION:CBL Seminar Room\, Engineering Department\, 4th floor Baker build
 ing
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