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SUMMARY:Transsaccadic working memory in healthy ageing and neurodegenerati
 ve disease - Stella Wernicke
DTSTART:20260327T140000Z
DTEND:20260327T150000Z
UID:TALK246109@talks.cam.ac.uk
CONTACT:Adam Triabhall
DESCRIPTION:This week we will discuss and debate a very recent paper by Zh
 ao and colleagues (2026).\n\nAbstract: “The brain continuously integrate
 s rapidly changing visual input across eye movements to maintain stable pe
 rception\, yet the precise mechanisms underpinning dynamic working memory 
 and how these break down in brain diseases remain unclear. We developed a 
 novel eye-tracking paradigm and computational models to investigate how sp
 atial and colour information are updated across saccades in the human brai
 n. Our findings reveal that saccades selectively impair spatial but not co
 lour memory. Computational modelling identified that spatial representatio
 ns are maintained in a dual eye-centred frame of reference which is active
 ly updated by a noisy memory of saccades but is vulnerable to interference
 . Using this model\, we found that specific mechanistic failures in initia
 l encoding and memory decay\, rather than the saccadic updating process it
 self\, account for spatial working memory deficits in Alzheimer’s and Pa
 rkinson’s disease. These results provide a mechanistic understanding of 
 how dynamic spatial memory operates in health and its disruption in neurod
 egenerative disorders” (Zhao et al.\, 2026).\n\nReference: Zhao\, S.\, P
 arr\, T.\, Udale\, R.\, Klar\, V.\, Davis Jones\, G.\, Scholcz\, A.\, … 
 Husain\, M. (2026). Transsaccadic working memory in healthy ageing and neu
 rodegenerative disease. eLife\, 14. https://doi.org/10.7554/eLife.109581.3
LOCATION:https://cam-ac-uk.zoom.us/j/92612577704?pwd=MUtqMjVQdXNmUTVIYjRkM
 G1NUW9GZz09
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