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SUMMARY:Why are the GATES still OPEN ? Understanding the Binding-Gating pr
 oblem of the receptors involved in Calcium signalling - Samir Khan
DTSTART:20100610T120000Z
DTEND:20100610T130000Z
UID:TALK24721@talks.cam.ac.uk
CONTACT:Dr James Kirkbride
DESCRIPTION:Calcium signalling is undoubtedly the most key process involve
 d in regulating diverse cellular processes in both health and disease. The
  highly versatile intracellular signal\, Calcium involves different spatia
 l-temporal dynamics and is controlled by the 2 Calcium-releasing ion chann
 els\, the Ryanodine and IP3 Receptors. It has been proposed that initial e
 vents of BINDING evoke conformational changes that lead to GATING or Calci
 um release by these receptors. Only a thorough understanding of the archit
 ecture of these 2 receptors will inform where and how these conformational
  changes occur within the receptors. This talk will provide an overview of
  what BINDING-GATING problem is and how Structural and Functional studies 
 of these receptors will help in revealing this mechanism.
LOCATION:Entertaining Room\, Darwin College
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