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SUMMARY:Modelling protrusion phenotypes and the force velocity relation to
  motile cells - Dr. Martin Falcke\, Mathematical Cell Physiology\, Max-Del
 bruck Centre for Molecular Medicine\, Berlin
DTSTART:20100512T103000Z
DTEND:20100512T113000Z
UID:TALK24736@talks.cam.ac.uk
CONTACT:18664
DESCRIPTION:We propose a mathematical model for simulating the leading-edg
 e dynamics of a migrating cell from the interplay among elastic properties
 \, architecture of the actin cytoskeleton\, and the mechanics of the membr
 ane. Our approach is based on the description of the length and attachment
  dynamics of actin filaments in the \nlamellipodium network. It is used to
  determine the total force exerted on the membrane at each position along 
 the leading edge and at each time step. The model reproduces the marked st
 ate switches in protrusion morphodynamics found experimentally between epi
 thelial cells in control conditions and cells expressing constitutively ac
 tive Rac\, a signaling molecule involved in the regulation of lamellipodiu
 m network assembly.\nThe model also suggests a mechanistic explanation of 
 experimental distortions in protrusion morphodynamics induced by deregulat
 ion of Arp2/3 and cofilin activity.\nWe also simulate the force velocity r
 elation of motile cells. To that end\, we supplement the model by simple g
 el dynamics. We compare simulated force-velocity relations with experiment
 al results.\n
LOCATION:Seminar Room\, Centre for Physics of Medicine (PoM)
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