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SUMMARY:The rational design of small-molecule Neuropilin-1 antagonists - T
 revor Perrior\, Research Director of Domainex
DTSTART:20100714T091500Z
DTEND:20100714T100000Z
UID:TALK24880@talks.cam.ac.uk
CONTACT:Marko Hyvonen
DESCRIPTION:\nNeuropilin-1 (NRP1) is a receptor for vascular endothelial g
 rowth factor A165 (VEGF-A) and the neuronal guidance molecule semaphorin 3
 A (SEMA3A)\, which plays a key role in vascular and neuronal development. 
 Molecules which antagonise the interaction of NRP-1 with its protein ligan
 ds may be useful in a number of therapeutic settings\, in particular for t
 he treatment of certain types of cancer.\n\nIn collaboration with our clie
 nt\, Ark Therapeutics\, and with scientists at University College London\,
  we have designed the first small-molecule inhibitors of this protein-prot
 ein interaction and have shown that they display the expected pharmacologi
 cal profile.  This talk will describe our rational approach to the identi
 fication of the binding mode of the natural ligands\, and how we used this
  information to drive the de novo design of antagonists that provide a che
 mical template from which clinically useful therapeutic agents can be evol
 ved.\n\n
LOCATION:Seminar Room\, Sanger Building
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