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SUMMARY:“Disordered Proteins and their Dynamic Complexes in Biological R
 egulation” - Prof. Julie Forman-Kay (University of Toronto)
DTSTART:20100712T110000Z
DTEND:20100712T120000Z
UID:TALK24883@talks.cam.ac.uk
CONTACT:8272
DESCRIPTION:Intrinsic disorder is widely found in eukaryotic proteins invo
 lved in regulatory processes\, with a dominant role in mediating protein r
 ecognition. Our view of protein complexes has been shaped by static crysta
 l structures of folded proteins interacting via well-ordered\, complementa
 ry surfaces. However\, many important regulatory interactions may involve 
 'dynamic' complexes\, as intrinsically disordered protein regions do not a
 lways stably fold upon binding. We have utilized NMR and SAXS data in conj
 unction with our computational algorithm ENSEMBLE to describe the disorder
 ed state ensembles of the cyclin dependent kinase inhibitor Sic1 and the C
 FTR regulatory (R) region\, as well as their dynamic complexes. Comparison
  of our results to biological data provides insight into the unique modes 
 of regulation mediated by such highly dynamic complexes.
LOCATION:Unilever Lecture Theatre\, Unilever Centre\, Department of Chemis
 try
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