BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Emergence of HIV drug resistance during combinational therapy. - J
 ohn Kitayimbwa
DTSTART:20100520T153000Z
DTEND:20100520T163000Z
UID:TALK24946@talks.cam.ac.uk
CONTACT:Olivier Restif
DESCRIPTION:We investigate the factors that determine the emergence of a d
 rug-resistant HIV strain during the course of combination therapy. Using a
  within-host model for the dynamics of HIV\, we study conditions under whi
 ch mutant variants are selected in the presence  of drug pressure and domi
 nate the virus population. Local and global stability of resultant equilib
 rium points are discussed. An optimal combinational treatment regime that 
 seeks to maximize the benefits of treatment while minimizing viral loads a
 nd side effects of the treatment regimen involved is explored. Preliminary
  results suggest that an optimal length of “drug holiday” can be found
 \, which makes structured treatment plausible in the administration of ART
 .
LOCATION:Meeting Room 14\, Centre for Mathematical Sciences
END:VEVENT
END:VCALENDAR