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SUMMARY:Adult neurogenesis modulates the hippocampus-dependent period of f
 ear memory - Kaoru Inokuchi\, University of Toyama\, Toyama \, Japan
DTSTART:20100625T120000Z
DTEND:20100625T130000Z
UID:TALK25241@talks.cam.ac.uk
CONTACT:19092
DESCRIPTION:Acquired memory initially depends on the hippocampus (HPC) for
  the process of cortical permanent memory formation. The mechanisms throug
 h which memory becomes progressively independent from the HPC remain unkno
 wn. In the HPC\, adult neurogenesis has been described in many mammalian s
 pecies\, even at old ages. Using two mouse models in which hippocampal neu
 rogenesis is physically or genetically suppressed\, we show that decreased
  neurogenesis is accompanied by a prolonged HPC-dependent period of associ
 ative fear memory. Inversely\, enhanced neurogenesis by voluntary exercise
  sped up the decay rate of HPC-dependency of memory\, without loss of memo
 ry. Consistently\, decreased neurogenesis facilitated the long-lasting mai
 ntenance of rat hippocampal long-term potentiation in vivo. These independ
 ent lines of evidence strongly suggest that the level of hippocampal neuro
 genesis play a role in determination of the HPC-dependent period of memory
  in adult rodents. These observations provide a new framework for understa
 nding the mechanisms of the hippocampal-cortical complementary learning sy
 stems.\nReference\nKitamura\, T.\, Saitoh\, Y.\, Takashima\, N.\, Murayama
 \, A.\, Niibori\, Y.\, Ageta\, H.\, Sekiguchi\, M.\, Sugiyama\, H. & Inoku
 chi\, K. Adult neurogenesis modulates the hippocampus-dependent period of 
 associative fear memory. Cell 139\, 814-827 (2009).\n\nFor further informa
 tion please see:\n\nhttp://www.med.u-toyama.ac.jp/bmb/index.html
LOCATION:Part 2 Room in the Genetics Department.
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