BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Accelerated substitution rates in non-coding sequence: Gene duplic
 ation\, transcription factor binding site turnover and biased gene convers
 ion. - Dennis Kostka\, Gladstone Institute\, UCSF
DTSTART:20100702T133000Z
DTEND:20100702T143000Z
UID:TALK25388@talks.cam.ac.uk
CONTACT:Xin Wang
DESCRIPTION:Differences in the gene regulatory network are hypothesized to
  contribute significantly to phenotypic divergence between and within spec
 ies. Non-coding sequences with bursts of lineage-specific changes are prom
 ising candidates\, because clusters of nearby substitutions are a hallmark
  of selection potentially modify evolutionarily conserved regulatory eleme
 nts. Performing a comprehensive\, genome-wide analysis\, we find that geno
 mic loci with high substitution rates in the human-chimp lineage are over-
 represented near genes that duplicated in the human-chimp ancestor. We als
 o developed a method to screen for nucleotide substitutions predicted to a
 ffect transcription factor binding. Rates of binding site divergence are e
 levated in non-coding sequences near duplicated loci with accelerated subs
 titution rates.\nFinally\, GC-biased gene conversion (gBGC) is a non-adapt
 ive\, recombination-associated explanation for accelerated substitution ra
 tes.\nExplicitly modeling this effect we re-analyze loci with the most pro
 nounced human specific acceleration in substitution rate (HARs) and find t
 hat the majority (~80%) is unlikely to be driven by gBGC alone.\n
LOCATION:Cancer Research UK Cambridge Research Institute\, Room 215
END:VEVENT
END:VCALENDAR