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SUMMARY:&quot\;GREAT improves functional interpretation of cis-regulatory 
 regions&quot\; - Michael Wilson (Cancer Research UK\, Cambridge Research I
 nstitute)
DTSTART:20101108T150000Z
DTEND:20101108T163000Z
UID:TALK25396@talks.cam.ac.uk
CONTACT:Stefan Gräf
DESCRIPTION:GREAT improves functional interpretation of cis-regulatory reg
 ions. \nC.Y. McLean\, D. Bristor\, M. Hiller\, S.L. Clarke\, B.T. Schaar\,
  C.B. Lowe\, A.M. Wenger and G. Bejerano. \nNature Biotechnology\, 28(5):4
 95-501\, 2010.\n\nhttp://www.nature.com/nbt/journal/v28/n5/full/nbt.1630.h
 tml\n\nWe developed the Genomic Regions Enrichment of Annotations Tool (GR
 EAT) to analyze the functional significance of cis-regulatory regions iden
 tified by localized measurements of DNA binding events across an entire ge
 nome. Whereas previous methods took into account only binding proximal to 
 genes\, GREAT is able to properly incorporate distal binding sites and con
 trol for false positives using a binomial test over the input genomic regi
 ons. GREAT incorporates annotations from 20 ontologies and is available as
  a web application. Applying GREAT to data sets from chromatin immunopreci
 pitation coupled with massively parallel sequencing (ChIP-seq) of multiple
  transcription-associated factors\, including SRF\, NRSF\, GABP\, Stat3 an
 d p300 in different developmental contexts\, we recover many functions of 
 these factors that are missed by existing gene-based tools\, and we genera
 te testable hypotheses. The utility of GREAT is not limited to ChIP-seq\, 
 as it could also be applied to open chromatin\, localized epigenomic marke
 rs and similar functional data sets\, as well as comparative genomics sets
 .
LOCATION:Room 132\, CRI
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