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SUMMARY:Options for in-focus phase contrast provided by additional relay o
 ptics - Dr. R.M. Glaeser\, Glaeser Lab\, Life Sciences Divison\, Lawrence 
 Berkeley National Lab\, CA
DTSTART:20100701T133000Z
DTEND:20100701T143000Z
UID:TALK25401@talks.cam.ac.uk
CONTACT:Dr Christopher John Edgcombe
DESCRIPTION:We are interested in the use of electron microscopy for applic
 ations in structural biology. Our current research activities include (1) 
 single-particle structure analysis of large\, multi-protein complexes\, wh
 ich is part of LBNL’s “Protein Complex Analysis Project (PCAP)”\, an
 d (2) development of the novel technology of Zernike phase contrast in tra
 nsmission electron microscopy. \nApplications of in-focus phase contrast i
 n electron microscopy will include (1) extending the scope of single-parti
 cle structure analysis to protein complexes as small as 200 kDa or less\, 
 (2) greatly improved morphological characterization of the “deconstructi
 on” process of lignocellulosic materials by cryo-EM tomography\, and (3)
  structural studies of membrane proteins within a “native-like” lipid 
 bilayer environment\, using single-particle reconstruction for purified pr
 oteins after reconstitution into lipid bilayers.\n
LOCATION:Mott Seminar Room\, Cavendish Laboratory\, Department of Physics
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