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SUMMARY:A systems-level view on post-transcription gene regulation - Prof.
  Yitzhak Pilpel\, Weizmann Institute\, Israel.
DTSTART:20100708T150000Z
DTEND:20100708T160000Z
UID:TALK25451@talks.cam.ac.uk
CONTACT:M. Madan Babu
DESCRIPTION:In the beginning of the genome era regulatory genomics mainly 
 addressed the level of transcription. In recent years part of the attentio
 n starts to shift towards regulation at the post-transcriptional\nlevel\, 
 mainly to further stages in RNA metabolism and to translation. A notion th
 at begins to appear with such recent studies is that the various levels of
  propagation of genetic information are often\ncoupled to one another\, su
 ch that activity at one level\, such as transcription\, might affect other
 s\, e.g. mRNA decay or translation. In this talk I will discuss our recent
  attempts to understand the\nstructure of genome-wide regulatory networks 
 that control post-transcription gene expression and the modes of their reg
 ulatory coupling. I will focus on two recent studies\, in the first we inv
 estigate a\nregulatory coupling between transcription and mRNA degradation
 . In this context I will discuss the intriguing possibility that during tr
 anscription of a gene the half life of its mRNA is already determined. In 
 a second part of the talk I will describe our investigations of regulatory
  sequences that control translation efficiencies\, and suggest a universal
  novel design of coding sequences that supports optimal translation\, and 
 that affects as a consequence mRNA decay rates.
LOCATION:Max Perutz Lecture Theatre\, MRC Laboratory of Molecular Biology\
 , Cambridge\, UK
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