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SUMMARY:Understanding variation in mRNA processing with RNA sequencing - P
 ickrell\, J (University of Chicago)
DTSTART:20100715T080000Z
DTEND:20100715T083000Z
UID:TALK25503@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:RNA sequencing allows the measurement of gene expression level
 s at unprecedented resolution. We have sequenced mRNA from lymphoblastoid 
 cell lines derived from 75 Nigerian individuals as part of the Internation
 al HapMap Project. I will discuss two aspects of these data with regards t
 o variation in mRNA processing. First\, I will describe how we are identif
 ying genetic variants which cause variation in mRNA splicing across indivi
 duals. Second\, I will show that splicing is an inherently noisy process w
 ithin individuals\, and that natural selection against this noise has infl
 uenced the sequence composition of genes. 
LOCATION:Seminar Room 1\, Newton Institute
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