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SUMMARY:Species specific transcription in mice carrying human chromosome 2
 1 - Odom\, D (University of Cambridge)
DTSTART:20100716T110000Z
DTEND:20100716T113000Z
UID:TALK25510@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Homologous sets of transcription factors direct conserved tiss
 ue-specific gene expression\, yet transcription factor binding events dive
 rge rapidly between closely related species.  We used hepatocytes from an 
 aneuploid mouse strain carrying human chromosome 21 to determine on a chro
 mosomal scale whether interspecies differences in transcriptional regulati
 on are primarily directed by human genetic sequence or mouse nuclear envir
 onment. Virtually all transcription factor binding locations\, landmarks o
 f transcription initiation\, and the resulting gene expression observed in
  human hepatocytes were recapitulated across the entire human chromosome 2
 1 in the mouse hepatocyte nucleus.  Thus\, in homologous tissues\, genetic
  sequence is largely responsible for directing transcriptional programs\; 
 interspecies differences in epigenetic machinery\, cellular environment\, 
 and transcription factors themselves play secondary roles.
LOCATION:Seminar Room 1\, Newton Institute
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