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SUMMARY:Morphology and proliferation of the mammalian spinal cord central 
 canal - Clara Alfaro Cervelló
DTSTART:20100922T110000Z
DTEND:20100922T000000Z
UID:TALK25701@talks.cam.ac.uk
CONTACT:Shannon Tinley-Browne
DESCRIPTION:Two neurogenic regions have been described in the adult brain\
 , the subventricular zone and the dentate gyrus subgranular zone. Stem cel
 ls in these regions have been extensively studied. However\, proliferating
  cells are found in other periventricular regions along the neuraxis\, inc
 luding the spinal cord central canal\, where the identity of the stem cell
 s is not known. In order to clarify which cell types proliferate in the ce
 ntral canal\, we performed a meticulous study of this region in the rodent
  and in the macaque. \n	The common cell type in the rodent spinal cord cen
 tral canal was an ependymal biciliated cell that lacked centrioles and dis
 played motile cilia with a basal body that differed from the basal bodies 
 of multiciliated ependymal cells. In contact with the lumen we also observ
 ed ependymal cells with one or three cilia\, astrocytes with a single cili
 um\, and neurons. The vast majority of actively dividing cells corresponde
 d to ependymal biciliated cells\, which generated new ependymal cells that
  contributed to the central canal length extension. \nThe macaque central 
 canal also contained ependymal cells\, astrocytes with a single cilium\, a
 nd neurons. In contrast to the rodent\, ependymal cells in the macaque spi
 nal cord were multiciliated\, biciliated and uniciliated. As in the rodent
 \, macaque central canal ependymal cells proliferated and gave rise to new
  ependymal cells. \n
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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